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COMBINATION THERAPIES In MASH, combination therapy directed at different pathways represents an attractive alternative to improve clinical efficacy and reduce adverse effects through lower doses or drugs with complementary actions 55

Additionally, the pAcF has become a widely applied ncAA in bioconjugate chemistry, particularly for antibody conjugation applications, owing to its well-established genetic encoding systems and proven biocompatibility profiles 24,25,26

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GLP-1 helps regulate blood sugar levels by stimulating the release of insulin, suppressing glucagon secretion (which raises blood sugar levels), and slowing the rate at which the stomach empties, leading to a feeling of fullness and reduced appetite.69 In addition to its use in diabetes management, GLP-1RA has also shown potential in other areas of research